Saturday, January 16, 2016

No-cost extensions of NIH grants - What I just learned

I learned something this month that surprised me about no-cost extensions of NIH grants, so I thought I’d share it.  A no-cost extension means that you are allowed to use money left over from the last year of your grant for an additional period of time.  From what I understand, NIH has granted universities the ability to simply request one extra year and this is automatically approved.  Again, no new money.  You’re just allowed to use up the money you didn’t spend in your last year of a grant. 

I had always assumed there was a limit of 25% of the money from your last year that you could carry forward to an extra year, but this is wrong.  I assumed this because in a multiyear grant like an R01, you cannot carry forward more than 25% of funding period 1’s (year 1’s) money into funding period 2 (year 2), for example. However, the no-cost extension is actually an extension of the length of time for the final funding period.  It is not considered carryover of funds into a new funding period.  Thus, the 25% rule does not apply.  This means that if you’re really worried about obtaining new funding (like I am), you can cut back in that final year of a grant and split the money over two years.  I’m not saying this is a good idea.  I’m just saying this option is available. 

Saturday, August 15, 2015

My department chair told me I'm planning too many grants

I had a meeting yesterday with my department chair.   I was really excited because I was just notified that I received the nomination from our university to apply for TWO(!) of the super fancy early career scholar awards.  I also had a department of defense grant make it through the pre-proposal phase.  Then I told my chair that I also wanted to write the new NIGMS MIRA grant that is due next month, as well as my R01 resubmission.  I basically have grants due every 2-3 weeks from now until Christmas. 

I don't think I wrote on this blog yet that my R01 for which I got an R56 actually scored much worse on its resubmission.  A LOT worse.  As in, I need to replace 2 of 3 aims, and completely re-write the third one.  The study section was completely re-populated and they just hammered everything this time. 

So it is imminent that my lab will have a funding gap, though technically with a no-cost extension of the R56, my salary requirement from the university will still be covered for another year.  But I feel like I cannot miss applying for any of these grants!  My department chair, on the other hand, told me that the quality of my applications will go down if I try to do all of these.  The chair said something to the effect of, "I know you're a workaholic, but nobody can submit this many grants in this amount of time while running a lab and teaching." 

The fancy scholar grants aren't really a lot of money in the grand scheme of things, but they basically set you on a path to being famous, and make you part of a cohort of famous scientists that you'll know for the rest of your career.  I think I would be regretful if I didn't give those my best shot.  The DOD grant is a lot of money and my research fits perfectly into one of this year's goals.  However, it's also a long application with a ton of paperwork.  MIRA is a pilot program and is also currently only open to new investigators and early stage investigators, so I may not be eligible in the future.  Plus, I think I'm a good candidate, so I can't see not applying to that one.  As for my R01, I also can't see not submitting a revised version, since scores almost always get better on a resubmission.  If I had to eliminate one, I think it would be the DOD grant, but I'm very open to any advice or suggestions. 

Wednesday, July 15, 2015

"Decision in Process" at PLOS

A manuscript from my lab is under consideration at a PLOS journal that is one of the top journals in my field.  The paper came back from the first round of review with a decision of major revisions, and we sent it back after addressing most of the reviewer concerns.  The online status said "Under Review" for roughly two weeks and then changed to "Decision in Process."  I first noticed this yesterday morning so I thought I would surely receive the decision by the end of the day.  Well, it's now the end of day two with this status and still no email from the journal.  So I did a little internet searching about what this actually means.  According to the PLOS website, this means that the handling editor has already entered a decision, but that it is not yet finalized.  It's unclear what the holdup is, but perhaps the decision also needs to be approved by the Section Editor.  So why do they change the status???!!!  No other journals do this, and it is like torture for me and my students to know that a decision has been made, but for some unknown reason it is has been withheld from us for 2+ days. 

Update:  The decision came after 4 days.  Two reviewers were completely satisfied by the revision and had no further concerns.  The third reviewer asked us to do additional experiments to address peripheral issues and also to change our title.  I am assuming that the handling editor and section editor spent time evaluating the requests of reviewer 3, so I guess I now understand the apparent delay.  They ultimately chose to accept the paper.  Wooohooooo!!!!

Saturday, May 30, 2015

Waiting for my study section to meet

My study section meets on Monday to review the third submission of my R01 on my lab's main project.  When I think about it, I get this tightening in my stomach and feel like I can't breathe, so I thought I'd write a blog post about it. 

One thing that I thought might make me feel better was to look at the roster for the study section, which is posted around this time prior to the review.  I can identify one ideal reviewer who was probably brought on as an ad hoc reviewer specifically for my grant, but I have no idea who the other two reviewers would be.  So looking at the roster just made me more anxious. 

I don't really have much more to say except that if you feel this intense anxiety too while thinking about your grant reviews, you are not alone!

Tuesday, May 5, 2015

I hate reviewers for low impact factor journals

I'm seriously irritated.

We just got reviews back from a journal with a relatively low impact factor, not terrible, but lower than ideal.  The reason I submitted there is that we have an intriguing finding that was made by a medical student who worked in my lab last summer, but since he was only around for the summer, we don't have a ton of data. It's also not something I want to devote additional resources towards.  But again, he made one main discovery, and I've gone on myself to corroborate this with an additional method, and I've added a few more figures so that there were a couple more points of interest to discuss in a manuscript.  The student really wants to get a publication out so that he can join the medical student honor society, so I told him we'd try to get it published.

I usually start by submitting to journals above where I really think it belongs and then go down the IF ladder from there. But this time I decided to start low so that it would definitely get accepted both for his application to the honor society and so I'd have another last-author publication for my grant review coming up next month.

Well, the reviewers, while overall positive about the manuscript, asked for just as many additional experiments as though it was being reviewed for Nature Genetics.  If we did all of these experiments (or had the will to do them), I certainly wouldn't be trying to publish in this low IF journal.  I know that we need to be scientifically rigorous, but don't reviewers also have to review with the realities of the specific journal in mind?  It's not like they were saying that what we did was bad, they just suggested a million more things to do, none of which would change the conclusion of the paper.

Major revisions.  So frustrated.   

Tuesday, April 28, 2015

Introducing yourself to important people at meetings

I am a shy person in a group setting, maybe even extremely so.  I feel absolutely comfortable meeting with even the most famous professors one-on-one in my office.  But, throw me in a crowded room during the coffee break at a conference and I'm useless. 

This past week I was at an international meeting with some of the most well-known people in my field.  I had one main goal for the week, and that was to introduce myself to the chair of the NIH study section that I primarily submit to.  And I did it!!!  I just sat myself one chair away from him at one of the sessions, made eye contact, and introduced myself.  We made 30 seconds of small talk, and it was actually pretty easy.  Turns out he has a postdoc starting a position at a different institution in my city.  Now hopefully he'll at least vaguely remember me when my application comes up for review this summer. 

The other thing that I'm pretty happy about was that I made a point of also trying to meet all of the other new PIs who were at the meeting.  The organizers seemed to pick a lot of us early-stage faculty members to speak at the afternoon sessions (when most of the people were off sightseeing), so it was pretty easy to identify them.  I figure that we'll be the famous big shots at these meetings in 20 years, and these things might actually become enjoyable if I make friends while we're young. 

Saturday, March 14, 2015

Feeling terrible after giving a seminar

I’m writing this in response to a blog post by The NewPI.  She recently gave a talk at a meeting and left feeling pretty bad about it.  This wasn’t because anything particularly bad happened, but rather, she didn’t feel like it was as exciting as it could have been, and also because she didn’t really get much positive feedback. 

I have felt exactly the same way after every talk I’ve given since becoming a PI three years ago.  Seriously.  Every time.  But I’ve had two eye-opening experiences recently that I thought might be worth sharing. 

First, a couple weeks ago I went to a work-in-progress seminar for an assistant professor who is new to our institution and department, though she is quite an accomplished scientist.  A day or two after the seminar, she stopped by my office to ask if I would be willing to do a peer evaluation of her lecture.  She went on to say that she felt like she had disappointed everyone because no one said anything to her after her talk. It was like it was as though people just ignored the fact that she had just given this seminar that to her was a major milestone.  She wanted feedback about how she could improve.  I was SHOCKED to say the least.  Why?  Because her seminar was fantastic!  It was clear and full of new and interesting data.  So I told her this, and then realized that nobody in our department ever tells each other that they did a good job.  As a matter of fact, the people who get the most affirmation after giving a talk in our department are usually grad students who do a really bad job!  This was kind of a revelation for me when I realized that maybe all of MY bad talks aren’t really as bad as I think they are! 

Second, I was invited to give a talk at a nearby fancy teaching hospital.  They have a seminar series where a clinician presents background and a clinical case, and then a researcher presents whatever they’re doing in their lab to address this clinical problem.  The audience is pretty much a 50:50 mix of physicians and researchers.  The seminar counts for CME credit for the physicians, so I totally felt like I had to spin my research in the most clinically relevant way possible.  This isn’t much of a stretch for my work, but I’m not at all used to presenting it in this way or to this type of audience.  My portion of the seminar was also only supposed to be 20 minutes, so it was really challenging to explain things adequately.  While I was talking I felt like I was bombing the whole time.  People were getting up and leaving or standing up to get more pizza or looked like they were falling asleep.  Then at the end, all the questions were for the clinician and not me.  And as I was leaving, no one said anything to me at all.  It’s just such a strange feeling to be the center of attention as a seminar speaker and then be almost completely ignored after it's over.  I had been so anxious about this talk for months and I left feeling like I had completely failed.  Fast forward two weeks, and it turns out that as part of the CME credit requirements, the physicians in attendance filled out evaluation forms for both of us.  This was in a huge auditorium full of people and I got ranked all 9's and 10's for almost every aspect of the talk that they evaluated.  I seriously could not stop smiling for the rest of the day!  I was SO WRONG about how I had done.  I became even more convinced that lack of feedback after a talk and people ignoring you are probably strong indicators that you did a GOOD job. 

So, New PI, you probably did a lot better than you think!